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| SilenceSelect is a collection of shRNAs directed against over 4,500 human drugable transcripts. The use of the SilenceSelect adenoviral vectors results in the expression of shRNAs, which are further cleaved by the cell to form siRNAs. These siRNAs then facilitate efficient degradation of the mRNA of interest. Because the shRNAs are expressed in human cells over a long period of time (>10 days), complex assays, such as those involving cell differentiation can be performed. All of the protein classes that are considered amenable to small molecule intervention are thoroughly represented in this collection. SilenceSelect also covers an extensive number of antibody targets of high interest to the pharmaceutical industry.
Our target discovery platform is based on adenoviruses that efficiently introduce human cDNA or shRNA constructs into a wide variety of human primary cells to knock-in or knock-down specific human genes. In addition to our off-the-shelf cDNA and shRNA collections, we can generate adenoviruses expressing constructs to either over-express or knock-down your gene of interest. We also offer custom purification of our adenoviruses. The high standards of our purified reagents allows for the progression of projects to in vivo animal studies. More information about our FLeXSelect adenoviral library for the over-expression of human drugable full-length genes can be found at www.flexselect.net. |
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